If you look at the panel edges at the bottom of the page, you can see that the bottom one on the left more or less bleeds into the giant vertical panel on the right. This is unfortunate becaues it gives the impression of negative space where none should exist. The lesson learned here is that it’s a good idea to give your panel borders contrasting colors so that the seperation will be obvious to the reader.

(Heavy Metal issue #217, January 2005 – Page 56 Requiem #3 by Mills and Ledroit)